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Sensitive Quantitative Predictions of MHC Binding Peptide from Entamoeba Histolytica

Excerpt

Entamoeba histolytica is an anaerobic parasitic protozoan, infecting humans and other primates. Symptoms can include fulminating dysentery, bloody diarrhea, weight loss, fatigue, abdominal pain, and amoeboma. Peptide fragments of antigen protein can be used to select nonamers for use in rational vaccine design and to increase the understanding of roles of the immune system in infectious diseases. Analysis shows MHC class II binding peptides of antigen protein from Entamoeba histolytica are important determinant for protection of host form parasitic infection. In this assay, we used PSSM and SVM algorithms for antigen design and predicted the binding affinity of antigen protein having 335 amino acids, which shows 327 nonamers. Binding ability prediction of antigen peptides to major histocompatibility complex (MHC) class I & II molecules is important in vaccine development from Entamoeba histolytica.

  • Abstract
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  • Abbreviations:
  • I. Introduction
  • II. Methodology
  • III. Results and Interpretations
  • IV. Conclusion
  • V. References

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