Chapter 8
Characterization of Skeletal Muscle Elasticity Using Magnetic Resonance Elastography


Magnetic resonance elastography (MRE) is a non-invasive phase-contrast MR technique that directly visualizes and quantitatively measure propagating strain waves in tissue-like materials subject to harmonic mechanical excitation. A phase-contrast MRI technique is used to spatially map the shear wave displacement field, and local quantitative values of shear modulus are then calculated through various inversion algorithms, and elastogram generated. This information can be clinically useful to understand the effects of pathologies on the mechanical properties of skeletal muscle and to quantify the effects of treatment. In this chapter, the principles of MRE image acquisition and stiffness inversion algorithm are reviewed, specific instrumention to apply MRE on skeletal muscles are introduced, and unique challenges to MRE when applied on skeletal muscles are discussed.

  • Abstract
  • 8.1 Clinical Background
  • 8.2 Principle of MRE Imaging
  • 8.3 Introduction to Elasticity Inversion Algorithms
  • 8.3.1 Wave Motion in Elastic Solids
  • 8.3.2 Algebraic Inversion of the Differential Equation (AIDE)
  • 8.3.3 Phase Gradient
  • 8.3.4 A Finite Element Based Inversion Algorithm: Overlapping Subzone Technique
  • 8.4 Mechanical Characterization of Skeletal Muscles
  • 8.5 Applications of MRE to Skeletal Muscles
  • 8.5.1 Databases of Muscle Stiffness Using MRE
  • 8.5.2 Correlation of MRE Data With a Functional Examination
  • 8.5.3 Assessing Pathologic Muscle With MRE
  • References

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