Chapter 10
Non-Invasive Method for Measuring Local Viscoelasticity of Arterial Vessels


Pulse wave velocity (PWV) is widely used for estimating the stiffness of an artery. It is well known that a stiffened artery can be associated with various diseases and with aging. Usually, PWV is measured using the “foot-to-foot” method in which the travel time of the blood pressure wave is measured over a distance. The “foot” of the pressure wave is not clear due to reflected waves. Also, PWV is an average indicator of artery stiffness between the two measuring points, and therefore does not identify local stiffness. The authors have developed a wave method in which the localized ultrasound radiation force is non-invasively generated in the arterial wall. The velocity of wave propagation in the artery can be measured accurately over a few millimeters. A mathematical model for wave propagation along the artery is developed with which the viscoelasticity of the artery can be evaluated noninvasively and locally.

  • Abstract
  • 10.1 Introduction
  • 10.2 Theory
  • 10.3 Experiments
  • 10.4 Results and Discussion
  • 10.5 Conclusions
  • References

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