Chapter 13
Nanomechanical Cantilever Biosensors: Conceptual Design, Recent Developments, and Practical Implementation


Micro∕nanocantilever-based sensors have recently emerged as an effective means for label-free chemical and biological species detection. Selectivity, low cost, and easy mass production make them an enabling technology for micro-detection and nanodetection techniques. These sensors operate through the adsorption of species on the functionalized surface of cantilevers. Through this functionalization, molecular recognition is directly transduced into a micromechanical response. This chapter presents a brief overview of microcantilever-based biosensors fabrication, the underlying principles of operation, modeling frameworks, techniques of microcantilever actuation, common materials used in fabrication of these sensors, and biological species detection techniques. More specifically, a detailed description of different operational modes of microcantilever biosensors is presented, followed by a set of comprehensive mathematical modeling frameworks. The chapter concludes with clinical applications of this type of biosensor, along with a review of recent developments and representative practical examples.

  • Abstract
  • 13.1 Introduction
  • 13.2 Microcantilever-Based Biosensing
  • 13.2.1 Surface Stress Sensing
  • 13.2.2 Mass Sensing
  • 13.3 Different Bio-Detection Methods
  • 13.4 Modeling Microcantilever Beam With Adsorbed Biological Species
  • 13.4.1 Static Mode (Deflection-Detection Method)
  • 13.4.2 Dynamic Mode (Frequency-Response Measurement)
  • 13.5 Recent Advances in Nanomechanical Cantilever Sensors' Modeling and Sensitivity Enhancement
  • 13.6 Common Materials Used in Nanocantilever Biosensors
  • 13.7 Common Methods of Nanocantilever Actuation
  • 13.7.1 Actuation Due to Ambient Conditions
  • 13.7.2 Actuation Using External Energy Sources
  • 13.8 Common Methods of Signal Transduction
  • 13.8.1 Optical Readout
  • 13.8.2 Piezoresistive Readout
  • 13.8.3 Piezoelectric Readout
  • 13.8.4 Capacitive Readout
  • 13.9 Applications
  • 13.10 Summary
  • References

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In