Because of its reliability, accuracy and other limitations, the safety issues exist in such electronic safety applications as airbag ignition system and fuze initiation. In this paper, a high-voltage piezoelectric actuator which is the combination of safety and environmental protection is designed. Utilized in vehicular airbag ignition systems, it can improve the reliability and accuracy. Firstly, the composition of system is discussed. It includes an inverter drive circuit, a Rosen piezoelectric transformer, an output circuit and feedback control circuit. Secondly, the brief components of high-voltage piezoelectric transformer are analyzed and designed in detail. In addition, implementation of high-voltage piezoelectric actuator is given. At last, some experiments are obtained here. These results show that the output voltage of this actuator is gained and controlled at 2.9kV-3.1kV in less than 600ms, which works in a high-efficiency constant current charging mode and in zero-voltage switching condition. This device has been utilized in a practical electronic safety system successfully.