Hollow fiber modules are commonly used to conveniently and efficiently remove cryoprotective agents (CPAs) from cryopreserved cell suspensions. In this paper, a steady-state model coupling mass transfers across cell and hollow fiber membranes is theoretically developed to evaluate the removal of CPAs from cryopreserved blood using hollow fiber modules. This steady-state model complements the unsteady-state model, which was presented in our previous study. The steady-state model, unlike the unsteady-state model, can be used to evaluate the effect of ultrafiltration flow rates on the clearance of CPAs. The steady-state model is validated by experimental results, and then is compared with the unsteady-state model. Using the steady-state model, the effects of ultrafiltration flow rates, NaCl concentrations in dialysate, blood flow rates and dialysate flow rates on CPA concentration variation and cell volume response are investigated in detail. According to the simulative results, the osmotic damage of red blood cells can easily be reduced by increasing ultrafiltration flow rates, increasing NaCl concentrations in dialysate, increasing blood flow rates, or decreasing dialysate flow rates.
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e-mail: dayong@u.washington.edu
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January 2010
Research Papers
A Steady-State Mass Transfer Model of Removing CPAs From Cryopreserved Blood With Hollow Fiber Modules
Weiping Ding,
Weiping Ding
Department of Mechanical Engineering,
University of Washington
, Seattle, WA 98195
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Xiaoming Zhou,
Xiaoming Zhou
Department of Mechanical Engineering,
University of Washington
, Seattle, WA 98195
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Shelly Heimfeld,
Shelly Heimfeld
Fred Hutchinson Cancer Research Center
, Seattle, WA 98109
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Jo-Anna Reems,
Jo-Anna Reems
Puget Sound Blood Center
, Seattle, WA 98104
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Dayong Gao
Dayong Gao
Department of Mechanical Engineering,
e-mail: dayong@u.washington.edu
University of Washington
, Seattle, WA 98195
Search for other works by this author on:
Weiping Ding
Department of Mechanical Engineering,
University of Washington
, Seattle, WA 98195
Xiaoming Zhou
Department of Mechanical Engineering,
University of Washington
, Seattle, WA 98195
Shelly Heimfeld
Fred Hutchinson Cancer Research Center
, Seattle, WA 98109
Jo-Anna Reems
Puget Sound Blood Center
, Seattle, WA 98104
Dayong Gao
Department of Mechanical Engineering,
University of Washington
, Seattle, WA 98195e-mail: dayong@u.washington.edu
J Biomech Eng. Jan 2010, 132(1): 011002 (7 pages)
Published Online: December 1, 2009
Article history
Received:
November 2, 2008
Revised:
June 18, 2009
Posted:
September 1, 2009
Published:
December 1, 2009
Online:
December 1, 2009
Citation
Ding, W., Zhou, X., Heimfeld, S., Reems, J., and Gao, D. (December 1, 2009). "A Steady-State Mass Transfer Model of Removing CPAs From Cryopreserved Blood With Hollow Fiber Modules." ASME. J Biomech Eng. January 2010; 132(1): 011002. https://doi.org/10.1115/1.4000110
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