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Journal Articles

Multiphysics Simulations of a Bioprinted Pulsatile Fontan Conduit

Open Access
Zinan Hu, Jessica E. Herrmann, Erica L. Schwarz, Fannie M. Gerosa, Nir Emuna, Jay D. Humphrey, Adam W. Feinberg, Tain-Yen Hsia, Mark A. Skylar-Scott, Alison L. Marsden
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2025, 147(7): 071001.
Paper No: BIO-24-1237
https://doi.org/10.1115/1.4068319
Published Online: May 15, 2025
View Articletitled, Multiphysics Simulations of a Bioprinted Pulsatile Fontan Conduit
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Topics: Bioprinting, Design, Electrophysiology, Fibers, Liver, Pressure, Simulation, Tension, Valves, Fluids
Journal Articles

Computational Study on the Effects of Valve Orientation on the Hemodynamics and Leaflet Dynamics of Bioprosthetic Pulmonary Valves

Available to Purchase
Kwang Bem Ko, Jung-Hee Seo, Ashish Doshi, Danielle Gottlieb Sen, Rajat Mittal
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. December 2024, 146(12): 121002.
Paper No: BIO-24-1133
https://doi.org/10.1115/1.4066178
Published Online: September 6, 2024
View Articletitled, Computational Study on the Effects of Valve Orientation on the Hemodynamics and Leaflet Dynamics of Bioprosthetic Pulmonary Valves
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Topics: Valves, Flow (Dynamics), Hemodynamics, Pulmonary artery, Pressure
Journal Articles

Simulated Effects of Acute Left Ventricular Myocardial Infarction on Mitral Regurgitation in an Ovine Model

Available to Purchase
Hao Liu, Michael S. Sacks, Natalie T. Simonian, Joseph H. Gorman, III, Robert C. Gorman
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. October 2024, 146(10): 101009.
Paper No: BIO-23-1153
https://doi.org/10.1115/1.4065376
Published Online: June 6, 2024
View Articletitled, Simulated Effects of Acute Left Ventricular Myocardial Infarction on Mitral Regurgitation in an Ovine Model
Open the PDF for Simulated Effects of Acute Left Ventricular Myocardial Infarction on Mitral Regurgitation in an Ovine Model in another window
Topics: Valves, Simulation, Deformation, Geometry, Myocardium
Journal Articles

Fluid Dynamic Study of the Penn State Pediatric Total Artificial Heart

Available to Purchase
Cody Kubicki, Emma Raich, Peter Selinsky, Sailahari Ponnaluri, William J. Weiss, Keefe B. Manning
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. October 2024, 146(10): 101007.
Paper No: BIO-23-1410
https://doi.org/10.1115/1.4065377
Published Online: May 13, 2024
View Articletitled, Fluid Dynamic Study of the Penn State Pediatric Total Artificial Heart
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Topics: Artificial hearts, Flow (Dynamics), Fluids, Particle image velocimetry, Pediatrics, Pumps, Rotational flow, Thrombosis, Valves
Includes: Supplementary data
Journal Articles

The Lymphatic Vascular System: Does Nonuniform Lymphangion Length Limit Flow-Rate?

Available to Purchase
C. D. Bertram
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. September 2024, 146(9): 091007.
Paper No: BIO-24-1032
https://doi.org/10.1115/1.4065217
Published Online: April 17, 2024
View Articletitled, The Lymphatic Vascular System: Does Nonuniform Lymphangion Length Limit Flow-Rate?
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Topics: Chain, Cycles, Flow (Dynamics), Pressure, Valves, Vessels
Includes: Supplementary data
Journal Articles

Enhancing Inhalation Drug Delivery: A Comparative Study and Design Optimization of a Novel Valved Holding Chamber

Available to Purchase
Shahab Azimi, Siamak Arzanpour
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. April 2024, 146(4): 041002.
Paper No: BIO-23-1276
https://doi.org/10.1115/1.4064436
Published Online: February 7, 2024
View Articletitled, Enhancing Inhalation Drug Delivery: A Comparative Study and Design Optimization of a Novel Valved Holding Chamber
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Topics: Design, Optimization, Particulate matter, Simulation, Valves, Drugs, Engineering prototypes, Flow (Dynamics), Drug delivery systems
Journal Articles

An In Silico Model for Predicting the Efficacy of Edge-to-Edge Repair for Mitral Regurgitation

Available to Purchase
Junichi Ooida, Naoki Kiyohara, Hironaga Noguchi, Yuichiro Oguchi, Kohei Nagane, Takuya Sakaguchi, Gakuto Aoyama, Fumimasa Shige, James V. Chapman, Masahiko Asami, Klaus Fuglsang Kofoed, Michael Huy Cuong Pham, Koshiro Suzuki
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2024, 146(2): 021004.
Paper No: BIO-23-1176
https://doi.org/10.1115/1.4064055
Published Online: December 12, 2023
View Articletitled, An In Silico Model for Predicting the Efficacy of Edge-to-Edge Repair for Mitral Regurgitation
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Topics: Deformation, Hemodynamics, Simulation, Valves, Maintenance, Optimization, Pressure
Journal Articles

Using a Mock Circulatory Loop as a Regulatory Science Tool to Simulate Different Heart Failure Conditions

Available to Purchase
Gavin A. D'Souza, Jean E. Rinaldi, Moustafa Meki, Annabelle Crusan, Eric Richardson, Meir Shinnar, Luke H. Herbertson
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. January 2024, 146(1): 011004.
Paper No: BIO-23-1170
https://doi.org/10.1115/1.4063746
Published Online: November 3, 2023
View Articletitled, Using a Mock Circulatory Loop as a Regulatory Science Tool to Simulate Different Heart Failure Conditions
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Topics: Fluids, Heart failure, Hemodynamics, Pressure, Testing, Valves, Flow (Dynamics), Diseases, Testing equipment, Cardiovascular system
Journal Articles

An Inverse Modeling Approach to Estimate Three-Dimensional Aortic Valve Interstitial Cell Stress Fiber Force Levels

Available to Purchase
Alex Khang, Kenneth Meyer, Michael S. Sacks
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. December 2023, 145(12): 121005.
Paper No: BIO-23-1085
https://doi.org/10.1115/1.4063436
Published Online: October 23, 2023
View Articletitled, An Inverse Modeling Approach to Estimate Three-Dimensional Aortic Valve Interstitial Cell Stress Fiber Force Levels
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Topics: Fibers, Hydrogels, Modeling, Stress, Valves
Includes: Supplementary data
Journal Articles

Benchtop Models of Patient-Specific Intraventricular Flow During Heart Failure and LVAD Support

Open Access
Vi Vu, Lorenzo Rossini, Juan C. del Alamo, Walter Dembitsky, Richard A. Gray, Karen May-Newman
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. November 2023, 145(11): 111010.
Paper No: BIO-23-1013
https://doi.org/10.1115/1.4063147
Published Online: September 4, 2023
View Articletitled, Benchtop Models of Patient-Specific Intraventricular Flow During Heart Failure and LVAD Support
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Topics: Flow (Dynamics), Heart failure, Valves, Ventricular assist devices, Vortices, Blood, Hemodynamics, Shear (Mechanics), Fluids
Includes: Supplementary data
Journal Articles

A Computational Pipeline for Patient-Specific Prediction of the Postoperative Mitral Valve Functional State

Available to Purchase
Hao Liu, Natalie T. Simonian, Alison M. Pouch, Paul A. Iaizzo, Joseph H. Gorman, III, Robert C. Gorman, Michael S. Sacks
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. November 2023, 145(11): 111002.
Paper No: BIO-23-1060
https://doi.org/10.1115/1.4062849
Published Online: August 2, 2023
View Articletitled, A Computational Pipeline for Patient-Specific Prediction of the Postoperative Mitral Valve Functional State
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Topics: Geometry, Valves, Simulation, Pipelines, Maintenance, Calibration, Imaging
Journal Articles

Simulating Subject-Specific Aortic Hemodynamic Effects of Valvular Lesions in Rheumatic Heart Disease

Free
Hannah L. Cebull, Olukayode O. Aremu, Radhika S. Kulkarni, Samuel X. Zhang, Petronella Samuels, Stephen Jermy, Ntobeko A.B. Ntusi, Craig J. Goergen
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. November 2023, 145(11): 111003.
Paper No: BIO-23-1101
https://doi.org/10.1115/1.4063000
Published Online: August 2, 2023
View Articletitled, Simulating Subject-Specific Aortic Hemodynamic Effects of Valvular Lesions in Rheumatic Heart Disease
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Topics: Aorta, Blood flow, Computational fluid dynamics, Diseases, Flow (Dynamics), Hemodynamics, Shear (Mechanics), Shear stress, Simulation, Statistical analysis
Includes: Supplementary data
Journal Articles

A New Dissipation Function to Model the Rate-Dependent Mechanical Behavior of Semilunar Valve Leaflets

Available to Purchase
Afshin Anssari-Benam, Yuan-Tsan Tseng, Martino Pani, Andrea Bucchi
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2023, 145(7): 071004.
Paper No: BIO-22-1272
https://doi.org/10.1115/1.4056917
Published Online: March 28, 2023
View Articletitled, A New Dissipation Function to Model the Rate-Dependent Mechanical Behavior of Semilunar Valve Leaflets
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Topics: Deformation, Energy dissipation, Mechanical behavior, Modeling, Stress, Valves
Journal Articles

From Scan to Simulation—A Novel Workflow for Developing Bioinspired Heart Valves

Open Access
Aeryne Lee, Syamak Farajikhah, Matthew Crago, Luke Mosse, David Frederick Fletcher, Fariba Dehghani, David Scott Winlaw, Sina Naficy
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Design Innovation Paper
J Biomech Eng. May 2023, 145(5): 055001.
Paper No: BIO-22-1195
https://doi.org/10.1115/1.4056353
Published Online: December 21, 2022
View Articletitled, From Scan to Simulation—A Novel Workflow for Developing Bioinspired Heart Valves
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Topics: Stress, Valves, Biomimetics, Geometry, Young's modulus, Workflow
Includes: Supplementary data
Journal Articles

The Accelerated Transcatheter Heart Valve Testing Environment: Loading, Motion, and Fluid Dynamics

Available to Purchase
Sailahari V. Ponnaluri, Michael S. Sacks, Keefe B. Manning
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. March 2023, 145(3): 031005.
Paper No: BIO-22-1215
https://doi.org/10.1115/1.4056291
Published Online: December 9, 2022
View Articletitled, The Accelerated Transcatheter Heart Valve Testing Environment: Loading, Motion, and Fluid Dynamics
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Topics: Flow (Dynamics), Valves, Pressure, Cycles, Turbulence
Journal Articles

A Physics-Guided Neural Operator Learning Approach to Model Biological Tissues From Digital Image Correlation Measurements

Free
Huaiqian You, Quinn Zhang, Colton J. Ross, Chung-Hao Lee, Ming-Chen Hsu, Yue Yu
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. December 2022, 144(12): 121012.
Paper No: BIO-22-1106
https://doi.org/10.1115/1.4055918
Published Online: October 28, 2022
View Articletitled, A Physics-Guided Neural Operator Learning Approach to Model Biological Tissues From Digital Image Correlation Measurements
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Topics: Biological tissues, Deformation, Displacement, Modeling, Physics, Valves, Constitutive equations, Testing, Errors
Journal Articles

Quantifying the Effect of Body Habitus on Cardiac Auscultation Via Computational Hemoacoustics

Available to Purchase
David Hojun Lee, Jung-Hee Seo, Rajat Mittal
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. February 2023, 145(2): 024503.
Paper No: BIO-22-1165
https://doi.org/10.1115/1.4055513
Published Online: October 6, 2022
View Articletitled, Quantifying the Effect of Body Habitus on Cardiac Auscultation Via Computational Hemoacoustics
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Topics: Blood flow, Elastic waves, Emission spectroscopy, Hemodynamics, Signals, Simulation, Spectroscopy, Valves, Computational methods, Modeling
Journal Articles

Estimation of Simulated Left Ventricle Elastance Using Lumped Parameter Modelling and Gradient-Based Optimization With Forward-Mode Automatic Differentiation Based on Synthetically Generated Noninvasive Data

Available to Purchase
Ryno Laubscher, Johan Van Der Merwe, Philip Herbst, Jacques Liebenberg
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2023, 145(2): 021008.
Paper No: BIO-22-1179
https://doi.org/10.1115/1.4055565
Published Online: October 6, 2022
View Articletitled, Estimation of Simulated Left Ventricle Elastance Using Lumped Parameter Modelling and Gradient-Based Optimization With Forward-Mode Automatic Differentiation Based on Synthetically Generated Noninvasive Data
Open the PDF for Estimation of Simulated Left Ventricle Elastance Using Lumped Parameter Modelling and Gradient-Based Optimization With Forward-Mode Automatic Differentiation Based on Synthetically Generated Noninvasive Data in another window
Topics: Cardiovascular system, Errors, Flow (Dynamics), Optimization, Pressure, Sensitivity analysis, Valves
Journal Articles

Regularization of a Mathematical Model of the Wheatley Heart Valve

Available to Purchase
R. J. Rebolledo, S. McKee, J. A. Cuminato, I. W. Stewart, D. J. Wheatley
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. January 2023, 145(1): 014501.
Paper No: BIO-21-1427
https://doi.org/10.1115/1.4055034
Published Online: August 19, 2022
View Articletitled, Regularization of a Mathematical Model of the Wheatley Heart Valve
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Topics: Valves
Journal Articles

Biomechanical Engineering Analysis of Pulmonary Valve Leaflet Hemodynamics and Kinematics in the Ross Procedure

Free
Yuanjia Zhu, Robert J. Wilkerson, Pearly K. Pandya, Danielle M. Mullis, Catherine A. Wu, Sarah Madira, Mateo Marin-Cuartas, Matthew H. Park, Annabel M. Imbrie-Moore, Y. Joseph Woo
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. January 2023, 145(1): 011005.
Paper No: BIO-22-1027
https://doi.org/10.1115/1.4055033
Published Online: August 19, 2022
View Articletitled, Biomechanical Engineering Analysis of Pulmonary Valve Leaflet Hemodynamics and Kinematics in the Ross Procedure
Open the PDF for Biomechanical Engineering Analysis of Pulmonary Valve Leaflet Hemodynamics and Kinematics in the Ross Procedure in another window
Topics: Flow (Dynamics), Hemodynamics, Kinematics, Valves, Flutter (Aerodynamics)
Includes: Supplementary data